Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a membrane protein primarily expressed in the prostate tissue, where it is localized in the plasma membrane of epithelial cells located at cell-to-cell junctions.1 STEAP1 expression is low or absent in normal tissues, and its expression is increased in several types of human cancers.1,2
1. Gomes IM, et al. Mol Cancer Res. 2012;10:573-587. 2. Barroca-Ferreira J, et al. Curr Cancer Drug Targets. 2018;18:222-230. 3. PR Newswire. https://www.prnewswire.com/news-releases/amgen-and-xencor-announce-strategic-collaboration-in-cancer-immunotherapy-and-inflammation-300143894.html. Accessed 9/10/20. 4. Amgen Pipeline. https://www.amgenpipeline.com. Accessed 9/10/20. 5. ClinicalTrials.gov. https://www.clinicaltrials.gov/ct2/show/NCT04221542. Accessed 9/10/20.